New research results published

Our laboratory has successfully developed an innovative single-cell RNA sequencing technology, and the results have been published in our sister journal “Molecular Cell” under the title “Single-cell resolution analysis reveals novel regulatory mechanisms in cancer metastasis”. The results were published in Molecular Cell, a sister journal of Cell, under the title “Single-cell resolution analysis reveals novel regulatory mechanisms in cancer metastasis”. In this study, we identified important molecular mechanisms in the early stages of metastasis by revealing subtle differences in gene expression in cancer cells that could not be captured by conventional methods. In particular, they found that a specific group of transcription factors plays a central role in enhancing the invasive potential of cancer cells. These results are expected to contribute to the development of new cancer treatment strategies. For more information, please see the paper.

Conference Presentation

Taro Yamada, a member of our laboratory, will give a presentation on the following topic at the 83rd Annual Meeting of the Molecular Biology Society of Japan to be held in Kyoto from June 15 to 18. Title: Chromatin dynamics analysis of neural stem cells using single-cell ATAC-seq In this presentation, we will report the results of our analysis of dynamic changes in chromatin structure during neural stem cell differentiation using state-of-the-art single-cell ATAC-seq technology. In particular, we will discuss how changes in chromatin accessibility in specific gene regions affect neuronal cell fate decisions, along with detailed data. We look forward to seeing you there.

New member joined our team

This spring we welcomed a new addition to our lab! Meiling Li is a very talented researcher specializing in genome informatics. She will be working on developing a new bioinformatics pipeline in single cell genomics analysis. We expect that the addition of Ms. Li will dramatically improve the data analysis capabilities of our laboratory. At the welcome party, all the members of the group expressed their support for Ms. Li's future endeavors, and the entire laboratory is committed to furthering her research efforts. We are looking forward to further development of our research with Ms. Li, who will bring a new breeze to our laboratory.

Press release published

The University's Public Relations Office has issued a press release regarding the new research result “Single-cell resolution analysis reveals novel regulatory mechanisms in cancer metastasis” published by our laboratory. The press release is available from the university's public relations department. The press release provides an easy-to-understand explanation of the significance of this research and its potential application to cancer treatment. Title of the press release: Elucidating the Key Molecular Mechanism of Cancer Metastasis with Innovative Single-Cell Analysis Technology For more information, please visit the university website. We hope many people will take a look.

New Year's Greeting

Happy New Year! I would like to express my sincere gratitude for your kindness and support during the past year. Thanks to all of you, last year was a fruitful year with the publication of new research results, presentations at conferences, and the addition of new members to our group. This year, we will continue to work together for the development of single-cell genomics research. We will do our best to meet your expectations, and we look forward to your continued support and encouragement. We sincerely wish you good health and happiness.

Grant-in-Aid for Scientific Research (A)

We are pleased to announce that our research project, “Elucidation of Disease Mechanisms by Innovative Single Cell Multilayer Omics Analysis and Application to Personalized Medicine,” has been selected as a Grant-in-Aid for Scientific Research (A) by the Japan Society for the Promotion of Science. This research aims to comprehensively understand cellular diversity and interactions in complex diseases by combining state-of-the-art single cell analysis technology with unique bioinformatics methods. In particular, the project will focus on intractable diseases such as cancer and autoimmune diseases to identify disease-specific cell populations and elucidate molecular mechanisms of therapeutic targets. Encouraged by the selection of this project, all of us in the laboratory will further pursue our research. We would like to express our deepest gratitude to all those involved for their support.

Participated in the international conference “Single Cell Biology 2024"

Sakura Suzuki and Kenta Tanaka from our laboratory recently attended the international conference “Single Cell Biology 2024” held in Boston, USA. The conference is an important gathering of the world's most advanced research in the field of single cell analysis, and we had the opportunity to learn about the latest research trends and innovations as well as present our research results. Suzuki gave a poster presentation on a new single-cell data analysis pipeline he is developing, which was the subject of a lively discussion. Tanaka gave an oral presentation on gene expression variation in specific cell populations, which provided valuable feedback from international researchers. He hopes to take advantage of the insights gained through this participation and new opportunities for collaboration to further develop his research activities in the future.

Laboratory Seminar was held

We recently held a seminar hosted by our laboratory. This time, we invited Dr. Ichiro Sato of the University of Tokyo to speak on the topic of “Multidimensional Analysis of Tissue Structure by Single Cell Spatial Transcriptomics. Dr. Sato is at the forefront of spatial transcriptomics and gave a very clear explanation of his innovative techniques and applications. A lively Q&A session ensued, attended not only by members of his laboratory but also by many people from inside and outside the university. This seminar was a valuable opportunity for us to gain new perspectives and ideas. We would like to express our sincere gratitude to Dr. Sato and to all participants. We will continue to actively hold laboratory seminars to deepen academic exchange.